Pathological responses to neoadjuvant immunochemotherapy: implications for survival and recurrence in patients with locally advanced esophageal squamous cell carcinoma.

ABSTRACT:

Background

This study evaluated the prognostic implications of pathological responses of primary tumors (PTs) and lymph nodes (LNs) among locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients received neoadjuvant immunotherapy combined with chemotherapy (nICT).

Methods

This study enrolled patients with LA-ESCC who underwent nICT combined with esophagectomy at Jiangsu Cancer Hospital. Two senior pathologists independently and systematically evaluated the postoperative pathological specimens in a double-blind manner. Tumor regression in PTs was assessed using the Becker criteria, while LNs regression grading was optimized using Harrell's concordance index and the Akaike Information Criterion. The primary endpoints were overall survival (OS) and progression-fre

SUBMITTER: Li Y 

PROVIDER: S-EPMC12523077 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature