SPOCD1 expression in clear cell renal cell carcinoma: its implications for the prognosis and immunotherapy.

ABSTRACT:

Background

Recent advancements in the study of SPOCD1 have highlighted its potential role in carcinogenesis. Nevertheless, the specific correlation between SPOCD1 expression level, survival outcomes, and immune cell infiltration in clear cell renal cell carcinoma (ccRCC) has not been fully elucidated.

Methods

To determine the possible connection between SPOCD1 expression levels, clinical pathological information, and overall survival (OS) in individuals with ccRCC, multiple databases encompassing TCGA, Gene Expression Profiling Interaction Analysis (GEPIA), and UALCAN were employed. Additionally, a comprehensive examination of the connection between tumor-infiltrating immune cells (TIIC) and SPOCD1 was executed through TIMER, GEPIA, and TISIDB databases. Western blot (WB) an

SUBMITTER: Xu W 

PROVIDER: S-EPMC12523094 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature