A chicken lncRNA is identified as a critical regulator that increases influenza virus replication by impairing innate antiviral responses.

ABSTRACT: Influenza A virus (IAV) poses a significant global health threat to both humans and animals. Increasing evidence highlights long noncoding RNAs (lncRNAs) as critical regulators of various physiological and pathological processes, but their roles in virus‒host interactions in chickens remain elusive. This study identified chicken lncRNAs and further investigated their functional involvement in IAV-host interactions. Transcriptome sequencing of chicken DF-1 cells revealed that 2118 lncRNAs were differentially expressed following H9N2 avian influenza virus infection. Among these, a lncRNA that we named lncRNA-up4 was significantly upregulated by H9N2 infection. LncRNA-up4 was predominantly localized in the nucleus but also detected in the cytoplasm. Furthermore, we found that the virus-induce

SUBMITTER: Sajjad N 

PROVIDER: S-EPMC12523108 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature