Longitudinal multi-omics analyses of chemotherapy-induced peripheral neuropathy in response to taxanes.

ABSTRACT:

Background

Taxanes are an effective class of chemotherapeutics, but they frequently cause chemotherapy-induced peripheral neuropathy (CIPN). CIPN complicates treatment, often leading to alterations or discontinuation. This study aims to elucidate mechanisms underlying CIPN associated with taxane administration in breast cancer patients, utilizing a multi-omic, longitudinal approach to characterize molecular changes over time that can help gain insight into the pathophysiology of CIPN.

Methods

We assessed 358 patients receiving taxanes in (neo)adjuvant chemotherapy regimens over 12 months, evaluating CIPN at seven time-points, including pre- and post-treatment. CIPN was defined as an increase of eight or more points from baseline linearized CIPN20 scores. Changes in 194 mRNAs

SUBMITTER: Sharma A 

PROVIDER: S-EPMC12523140 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature