Brief preoperative frailty predicts postoperative adverse outcomes in older patients with radical esophageal cancer surgery.

ABSTRACT:

Background

Frailty is increasingly becoming a powerful prognostic factor for cancer patients. The purpose of this study was to investigate the prognostic effect of 5-modified frailty index (mFI-5) on adverse outcomes after surgery in older patients with esophageal cancer over 65 years of age.

Methods

Patients over 65 years old who underwent esophagectomy between January 1, 2014 and January 31, 2017 were included in the study analysis. The mFI-5 variables include hypertension, type Ⅱ diabetes, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and independent functional status. Patients were divided into 3 groups: robust group (mFI-5, 0), prefrail group (mFI-5, 1) and frail group (mFI-5, 2 ~ 5). Primary outcome was 30-day mortality. Secondary outcom

SUBMITTER: Hao X 

PROVIDER: S-EPMC12523159 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature