Association between thoracic adiposity and survival in non-metastatic breast cancer.

ABSTRACT:

Background

Total adiposity measured by abdominal computed tomography (CT) at the third lumbar vertebrae (L3) has been associated with breast cancer survival, but most patients undergo chest CT. If adipose tissues at the thoracic level, including those surrounding the thoracic organs, are associated with survival, they could be used to inform care for significantly more breast cancer patients.

Methods

We included 2127 individuals aged 18-< 90, diagnosed with stage II-III breast cancer at Kaiser Permanente Northern California (2005-2019). Cross-sectional areas of adiposity were quantified at the fourth thoracic vertebrae (T4) and L3. Using multivariable Cox models, we estimated hazard ratios (HRs) and 95% confidence intervals to compare the strength of association of T4-level

SUBMITTER: Cao A 

PROVIDER: S-EPMC12523217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature