Approved Ambiguities: An Analysis of Applications for the Ethical Review of Animal Research in Sweden-Focusing on Harm, Benefit, and the 3Rs.

ABSTRACT: This study examines regulatory requirements concerning the ethical review of animal research in Sweden, in particular legal obligations placed on applicants, and to some extent on Animal Ethics Committees (AECs). It focuses on what information applying researchers are required to provide, to what extent submitted applications reflect the fulfilment of these requirements, and how the AECs handle the information they receive. The study emphasizes areas of concern critical for an ethical evaluation. By examining a selection of submitted applications, the study has found information about harm, benefit, and the 3Rs is often insufficient or occasionally altogether missing, thus hindering the AECs' performance of a harm-benefit analysis (HBA) and an assessment of how the applying researcher has

SUBMITTER: Jorgensen S 

PROVIDER: S-EPMC12523415 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature