Understanding the Will Rogers Phenomenon in Cholangiocarcinoma Research and Beyond.

ABSTRACT:

Background

The existing literature highlights a lack of comparative studies between subtypes of cholangiocarcinoma (CC) and the impact of misclassification on the epidemiological parameters.

Methods

A retrospective study was conducted to evaluate the surgical outcomes. The authors used Poisson regression with modified errors to calculate the risk ratios (RR) and reported post-estimation marginal effects. Coefficient estimates, variance inflation factors, and Pearson's goodness-of-fit test statistics were used to check for multicollinearity and model fit, respectively. We also performed a reclassification analysis by modeling Klatskin tumors (PCC) as extrahepatic (ECC), reclassifying them as intrahepatic (ICC), and comparing the corresponding changes in estimates.

Results<

SUBMITTER: Akhmedullin R 

PROVIDER: S-EPMC12523421 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature