Combining IMWG GA and hematopoietic score to optimize the evaluation of dynamic chemotherapy tolerance in multiple myeloma.

ABSTRACT:

Background

Chemotherapy tolerance significantly affects treatment efficacy and survival in multiple myeloma (MM), especially among frail patients. The International Myeloma Working Group Geriatric Assessment (IMWG GA) is widely used for frailty assessment, but limitations remain. Dynamic and integrated assessment approaches may improve risk stratification and support personalized treatment.

Methods

We retrospectively analyzed 111 newly diagnosed MM patients treated at the Third Affiliated Hospital of Sun Yat-sen University (Jan 2018-Jun 2024). IMWG GA and Hematopoietic Score (HS) were assessed at baseline and follow-up. Static and dynamic frailty assessments were compared. Chemotherapy-related adverse events (AEs) were graded per CTCAE 5.0.

Results

Chemotherapy tolera

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12523449 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature