Immune checkpoint inhibitor-induced nephrotic syndrome: a pharmacovigilance analysis of 404 FAERS cases and literature case series.

ABSTRACT: Immune checkpoint inhibitor (ICI)-related nephrotic syndrome is a rare but increasingly reported adverse event, where early-onset severe cases warrant heightened vigilance. This pharmacovigilance study assessed this correlation by analyzing the U.S. Food and Drug Administration's Adverse Event Reporting System (FAERS) database from Q1 2011 to Q1 2025. A total of 404 cases of ICI-related nephrotic syndrome were identified in the FAERS database, with 84.1% of cases related to programmed cell death protein 1 (58.9%) or programmed death-ligand 1 (25.2%) inhibitors. Disproportionality signals were observed for six ICI monotherapies and one combination therapy: atezolizumab (ROR 6.84; 95% CI: 5.58-8.40), avelumab (ROR 5.54; 95% CI: 2.64-11.63), nivolumab (ROR 4.37; 95% CI: 3.64-5.25), pembrolizu

SUBMITTER: Ye J 

PROVIDER: S-EPMC12523462 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature