Difference between cystatin C- and creatinine-based estimated glomerular filtration rate and incident hypertension and the mediating role of Triglyceride Glucose Index.

ABSTRACT: Estimated glomerular filtration rate (eGFR) is usually calculated based on serum creatinine (eGFR_Scr) or cystatin C (eGFR_CysC). This study aimed to investigate the association between cystatin C-creatinine eGFR discordance (ΔeGFR_CysC-Scr) and new-onset hypertension and to assess the mediating role of triglyceride glucose (TyG) index based on the China Health and Retirement Longitudinal Study. The ΔeGFR_CysC-Scr was calculated by eGFR_CysC - eGFR_Scr. A Cox proportional risk model was used to assess the association between ΔeGFR_CysC-Scr and risk of new-onset hypertension. The mediating role of TyG was assessed using mediation analysis, and thresholds were obtained via Receiver Operating Characteristic curve. A

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12523486 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature