DNA Hypermethylation at the Invasive Front of Oral Squamous Cell Carcinoma Confers Poorly Differentiated Characteristics and Promotes Migration of Cancer Cells.

ABSTRACT: Background/Objectives: Oral squamous cell carcinoma (OSCC) is a common and aggressive oral cancer with high recurrence and mortality rates, largely due to late diagnosis and metastasis. Epigenetic regulation, particularly aberrant DNA methylation, plays a critical role in cancer progression. Altered methylation patterns disrupt cancer-related gene regulation. Our previous study found that oral cancer patients exhibit increased synthesis of S-adenosyl-L-methionine, a key methyl donor for cytosine methylation. Therefore, the aim of this study was to explore the relationship between global DNA methylation and OSCC progression and to evaluate the impact of DNA methylation heterogeneity on oral cancer cells. Methods: Immunohistochemistry (IHC) and immunofluorescence (IF) staining

SUBMITTER: Wang LP 

PROVIDER: S-EPMC12523504 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature