<i>SPP1</i> as a Potential Stage-Specific Marker of Colorectal Cancer.

ABSTRACT: Background: Colorectal cancer is the third most diagnosed cancer and a leading cause of cancer-related deaths worldwide. Early detection significantly improves patient outcomes, yet many cases are identified only at late stages. The high molecular and genetic heterogeneity of colorectal cancer presents major challenges in accurate diagnosis, prognosis, and therapeutic stratification. Recent advances in gene expression profiling offer new opportunities to discover genes that play a role in colorectal cancer carcinogenesis and may contribute to early diagnosis, prognosis prediction, and the identification of novel therapeutic targets. Methods: This study involved 142 samples: 84 primary tumor samples, 27 liver metastases, and 31 adjacent non-tumor tissues serving as controls. R

SUBMITTER: Turyova E 

PROVIDER: S-EPMC12523512 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature