Newer Insights on the Occurrence of Sarcopenia in Pediatric Patients with Cancer: A Systematic Review of the Past 5 Years of Literature.

ABSTRACT:

Background/objectives

Sarcopenia, defined as the progressive loss of muscle mass and function, is increasingly recognized in pediatric cancer patients as a significant clinical and prognostic factor. Sarcopenia in children arises from malignancy-related inflammation, malnutrition, and treatment toxicity, negatively affecting treatment response, recovery, and quality of life.

Methods

We searched MEDLINE and Scopus for English-written articles published over the last five years using synonyms for the terms "sarcopenia" and "pediatric cancer". Screening and data extraction were performed in a duplicate-blinded method. We qualitatively synthesized eligible articles.

Results

Recent studies identify pre-treatment sarcopenia as a marker of poor prognosis, especially in hepat

SUBMITTER: Kiosis G 

PROVIDER: S-EPMC12523584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature