Mechanistic Elucidation of the Anti-Ageing Effects of <i>Dendrobium officinale</i> via Network Pharmacology and Experimental Validation.

ABSTRACT: Dendrobium officinale (Orchidaceae) is a commonly used medicinal and edible herb. Although its anti-ageing properties have been demonstrated, the underlying mechanisms remain unclear. We employed network pharmacology and molecular biology techniques to systematically explore its anti-ageing mechanisms. An ageing model was established using D-galactose-induced Kunming mice. D. officinale significantly ameliorated ageing-related symptoms, including behavioural impairment and organ index reduction. It enhanced antioxidant capacity by increasing serum T-AOC levels and restoring renal activities of key antioxidant enzymes (SOD, GSH-Px, CAT) while reducing MDA; it suppressed serum TNF-α levels, indicating anti-inflammatory effects. Histopathological examination revealed that D.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12523731 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature