Comprehensive Evaluation of Hepatotoxicity Following Radiation Therapy in Breast Cancer Patients.

ABSTRACT: Purpose: The liver is susceptible to adverse effects from radiation therapy (RT) and systemic therapy (ST) for breast cancer, given its anatomical proximity. Thus, we evaluated hepatotoxicity after RT and ST for breast cancer. Methods: This multicenter retrospective study included breast cancer patients treated with RT in 2021 and underwent a liver function test (LFT) before and after RT. Patients with bilateral breast cancer or a history of thoracic or abdominal RT and liver disease were excluded. Changes in Common Terminology Criteria for Adverse Events (CTCAE) grading of liver enzyme elevation (LEE) of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and its associations with Dose-volume histogram (DVH) parameters and other c

SUBMITTER: Song JY 

PROVIDER: S-EPMC12523911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature