Curcumin mitigates the histopathological and molecular changes in sublingual glands in diabetic male rats.

ABSTRACT:

Objective

demonstrate the possible palliative role of curcumin in the prospective molecular and histological alterations in the sublingual glands of diabetic male rats.

Methods

Twenty-one male adult rats were used and randomly assigned into three groups (n = 7). The control group consisted of rats administered a single IP injection of saline. The diabetic group included rats receiving one dose of alloxan (140 mg/kg). The nanocurcumin-treated rat group (NC group) contained diabetic rats administered 200 mg/kg nanocurcumin. After 42 days, the salivary glands were dissected and assessed for Masson trichrome, Hematoxylin and eosin (H&E) staining, expression of c-kit and β-catenin, and histomorphometric analysis.

Results

The sublingual glands of diabetic rats revealed alte

SUBMITTER: El Shahawy M 

PROVIDER: S-EPMC12524023 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature