Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression.

ABSTRACT:

Background

Major depressive disorder (MDD) and treatment-resistant depression (TRD) have each been characterized by altered neural connectivity largely associated with the triple model of the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. However, the direction (i.e., hyper- vs. hypoconnectivity) and the specificity (i.e., depression broadly vs. TRD) of these alterations remains unclear. Thus, in the current study, we compared high-frequency between- and within-network resting-state functional connectivity (rsFC) in healthy control (HC) individuals, individuals with MDD, and individuals with TRD.

Methods

Ninety-six channel resting-state electroencephalogram data were collected from 34 participants with MDD (22 women, mean ± SD age: 29.92 ± 9.57 years),

SUBMITTER: Lees T 

PROVIDER: S-EPMC12524030 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature