The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy-A Systematic Review.

ABSTRACT:

Background

Interleukin-6 (IL-6) is used as a marker for infection and inflammation. After liver surgery, IL-6 is also crucial for hepatic regeneration. The value of IL-6 serum-levels to differentiate infection from imminent post-hepatectomy liver failure (PHLF) remains unclear. This review focuses on IL-6 and complications after liver resections, specifically PHLF and infections.

Methods

A systematic review was performed in the PubMed, Embase, and Cochrane libraries from January 2000 to June 2025 according to PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). All English language human data publications were assessed.

Results

Overall, 12 studies (n = 589 patients) evaluating perioperative serum IL-6 levels were included. Six

SUBMITTER: Kofler A 

PROVIDER: S-EPMC12524086 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature