Efficacy of a Once-Daily Supplement in Managing Canine Chronic Kidney Disease.

ABSTRACT:

Background

Chronic kidney disease (CKD) in companion animals leads to progressive renal deterioration and metabolic complications such as hyperphosphatemia and metabolic acidosis, particularly in advanced stages.

Methods

This 90-day, double-blind, randomized controlled study evaluated the effects of a renal supplement (Renal Combi, Candioli srl, Beinasco, Turin, Italy) in 30 dogs diagnosed with CKD. Dogs were randomly assigned to a treatment group (TRT, n = 15), receiving a commercial renal diet plus the supplement (once daily), or a control group (CTR, n = 15), receiving the same diet and a placebo.

Results

Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintain

SUBMITTER: Perondi F 

PROVIDER: S-EPMC12524088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature