Anti-tumor Effects of <i>Hedyotis diffusa</i> Willd on Cervical Cancer: Inhibition of Proliferation, Migration, and Induction of Apoptosis.

ABSTRACT:

Background

Cervical cancer is among the most prevalent malignancies affecting women globally. This study examines the anti-tumor effects and mechanisms of Hedyotis diffusa Willd (HDW), a traditional Chinese medicinal herb, on cervical cancer.

Methods

The effects of HDW on the proliferation and migration of SiHa and CaSki cells were evaluated through in vitro assays. Additionally, the anti-tumor activity of HDW was assessed in vivo using a xenograft mouse model. To further explore its potential mechanisms, the effects of HDW on apoptosis, the cell cycle, and the IL-17/NF-κB signaling pathway were analyzed.

Results

In vitro, HDW dose-dependently reduced the proliferation, colony formation, and migration of SiHa and CaSki cervical cancer cells (P < 0.01). It induc

SUBMITTER: Yang S 

PROVIDER: S-EPMC12524121 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature