Speculation on the Mechanism of Parkinson's Disease Induced by Risk Residual Pesticides in Fresh Jujube and Hawthorn Through Network Toxicology and Molecular Docking Analysis.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disease that is closely related to genetic and environmental factors, among which pesticide exposure is considered an important risk factor. Fresh jujube and hawthorn, as widely consumed fruits, may contain pesticide residues, but the potential effects of long-term low-dose intake on PD are not yet clear. This study combines network toxicology and molecular docking technology to elucidate the molecular mechanism of PD induced by residual pesticides in fresh jujube and hawthorn. Firstly, common risk pesticides (such as organophosphates and pyrethroids) in fresh jujube and hawthorn were screened through the database. Subsequently, a "pesticide target-PD" interactive network was constructed using network toxicology to predict key targets and rel

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12524234 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature