Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disorder characterized by chronic inflammation, impaired lubrication, and progressive cartilage degradation. To address these multifaceted pathologies, we developed a multifunctional nanoparticle, termed HPQ@K, based on hyaluronic acid (HA), for co-delivery of quercetin (QUT) - a compound with anti-inflammatory, antioxidant, and hyaluronidase properties - and kartogenin (KGN), which induces chondroautophagy and cartilage regeneration. QUT was conjugated to HA through reactive oxygen species (ROS)- and pH-sensitive boronate ester linkages, leading to self-assembled micelles that encapsulate KGN and enable stimulus-responsive drug release under inflammatory OA conditions. HPQ@K retains the innate lubricity and biocompatibility of HA, while exhibiti

SUBMITTER: Gan X 

PROVIDER: S-EPMC12524341 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature