"Top-down and Bottom-up" cholesterol-depleting biomimetic nanoparticle for enhancing sonodynamic therapy against hepatocellular carcinoma.

ABSTRACT: Cholesterol depletion in tumor cells has been demonstrated as an effective strategy for cancer therapy. Previous studies have shown that cholesterol oxidase (COD) could promote cholesterol consumption. However, these tumor cells typically upregulate cholesterol synthesis as a compensatory mechanism to meet the rapid proliferation demands. To address this issue, we synthesized HM/ZIF-8@COD/IR820 nanoparticle, which simultaneously facilitates cholesterol depletion and inhibits cholesterol synthesis to enhance sonodynamic therapy against hepatocellular carcinoma (HCC). This HM/ZIF-8@COD/IR820 biomimetic nanoparticle was constructed by encapsulating cholesterol oxidase (COD) and the sonosensitizer indocyanine green (IR820) into ZIF-8 nanoparticle, followed by coating with a hybrid cell membran

SUBMITTER: Yang M 

PROVIDER: S-EPMC12524343 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature