CTCF Mediates the Cis-Regulatory Hubs in Mouse Hearts.

ABSTRACT: The 3D chromatin architecture establishes a complex network of genes and regulatory elements necessary for transcriptomic regulation in development and disease. This network can be modeled by cis-regulatory hubs (CRH), which underscore the local functional interactions between enhancers and promoter regions and differ from other higher-order chromatin structures such as topologically associated domains (TAD). The activity-by-contact (ABC) model of enhancer-promoter regulation has been recently used in the identification of these CRHs, but little is known about the role of transcription factor CCTC binding factor (CTCF) on ABC scores and their consequent impact on CRHs. Here, we show that the loss of CTCF leads to a reorganization of the ABC-derived rankings of putative enhancers in the mou

SUBMITTER: Lee M 

PROVIDER: S-EPMC12524426 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature