Graft Polymers Derived from Pharmaceutically Active Choline-Based Ionic Liquid Monomers: Dual Incorporation of Ampicillin and Cloxacillin.

ABSTRACT: This study reports the synthesis and characterization of well-defined ionic graft conjugates acting as drug delivery systems, based on monomeric ionic units derived from choline methacrylate (TMAMA) biofunctionalized with the anions of ampicillin (AMP) or cloxacillin (CLX). Using the "grafting from" technique with multifunctional macroinitiators, the density of side chains was precisely defined, and the length of side chains was well-controlled during polymerization. The resulting ionic conjugates featured the regulated content of ionic fractions with drug anions reaching up to 55% and drug content up to 48-70% for AMP, 27-65% for CLX, and 47-79% for (CLX + AMP). The drug release behavior was evaluated under physiological conditions using a dialysis method. The ionic conjugates demonstrate

SUBMITTER: Mazur A 

PROVIDER: S-EPMC12524462 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature