Association between HOMA-IR and metabolic dysfunction-associated steatohepatitis in U.S. adults with MASLD.

ABSTRACT:

Background

MASH is a critical point in metabolic dysfunction-associated steatotic liver disease (MASLD). Understanding its association with the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) is essential, as HOMA-IR is a marker for insulin resistance.

Methods

This study analyzed 700 adults from the NHANES 2017-2020, using the FAST score (with thresholds of ≥0.35 and ≥ 0.67) to identify individuals at high MASH risk. Logistic regression assessed HOMA-IR's association with MASH risk, while linear regression evaluated its link to liver stiffness measurement (LSM) and controlled attenuation parameter (CAP). Nonlinear associations were explored using restricted cubic splines (RCS), and BMI's mediation effects were examined through causal mediation analysis.

Resul

SUBMITTER: Tang XX 

PROVIDER: S-EPMC12524561 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature