Structures, Interactions, and Antimicrobial Activity of the Shortest Thanatin Peptide from <i>Anasa tristis</i>.

ABSTRACT: Antimicrobial peptides (AMPs), also referred to as host defense peptides, are promising molecules in the development of the next generation of antibiotics against drug-resistant bacterial pathogens. Thanatin comprises a family of naturally occurring cationic AMPs derived from several species of insects. The first thanatin, 21 residues long, was identified from the spined soldier bug, and more thanatin peptides have been discovered in recent studies. The 16-residue thanatin from Anasa tristis, or Ana-thanatin, represents the shortest sequence in the family. However, the antimicrobial activity and mechanistic process underpinning bacterial cell killing have yet to be reported for Ana-thanatin peptide. In this work, we examined the antibacterial activity, structures, and target interac

SUBMITTER: Abdullah SJ 

PROVIDER: S-EPMC12524584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature