The Role of TRP Channels in Colitis and Inflammatory Bowel Disease: A Systematic Review.

ABSTRACT: Comprising ulcerative colitis (UC) and Crohn's disease (CD), inflammatory bowel disease (IBD) denotes a series of long-standing, relapsing inflammatory disorders of the digestive tract. There is increasing evidence in the literature indicating that IBD pathogenesis is associated with the dysfunction of ion channels, with Transient Receptor Potential (TRP) channels being of particular importance. Through this systematic review, the significance of various TRP channel types in the pathogenesis of colitis and IBD will be appraised. A comprehensive literature search was conducted in PubMed, ScienceDirect, and Google Scholar, encompassing original research articles, using the principles of the PRISMA statement (last search: 15 May 2025). The search terms used were "Transient Receptor Potential

SUBMITTER: Dvornikova KA 

PROVIDER: S-EPMC12524589 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature