The Role of the MntABC Transporter System in the Oxidative Stress Resistance of <i>Deinococcus radiodurans</i>.

ABSTRACT: The accumulation of high levels of manganese ions complexed with small molecules has been proposed as a pivotal factor contributing to the extraordinary radiation resistance of Deinococcus radiodurans. However, the molecular mechanisms governing the manganese ion homeostasis remain elusive. In this study, we characterize the role of the MntABC transporter system for Mn ion accumulation in D. radiodurans. Its cellular membrane localization is unequivocally demonstrated through fluorescence labeling techniques. Mutation of the protein components of the MntABC led to a significant decrease in intracellular Mn ion accumulation, concomitant with impaired cellular growth, decreased resistance against hydrogen peroxide, and gamma-ray irradiation-induced oxidative stresses, in

SUBMITTER: Wang B 

PROVIDER: S-EPMC12524626 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature