Comparative Proteomics, Functional Characterization and Immunological Cross-Reactivity Studies on Russell's Viper Venom from Two Distinct Geographical Regions in South India.

ABSTRACT: Snakebite envenoming is a neglected tropical disease contributing to a significant number of morbidities and mortalities globally. Reports indicate that venom variation influences antivenom efficacy, which might affect treatment outcomes. The venom composition of Daboia russelii (Russell's viper), one of the big four snakes in India, has been extensively studied from different geographical regions of India. Nonetheless, the Russell's viper venom proteome from Kerala (Western Ghats region), together with its study in comparison with the same species' venom from Tamil Nadu, has not been explored yet. In the current study, Daboia russelii venom from Irula (RVi) and the Western Ghats region in Kerala (RVwg) was characterized through mass spectrometry-based proteomics and few func

SUBMITTER: Reghu N 

PROVIDER: S-EPMC12524627 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature