Synovial <i>CXCL3</i>⁺<i>FOSL2</i>⁺ Macrophages Mediate Inflammation via <i>FOSL2</i>/AP-1 in Rheumatoid Arthritis: A Single-Cell Transcriptome Analysis.

ABSTRACT: Macrophages play a central role in joint inflammation and bone destruction in rheumatoid arthritis (RA). While activator protein-1 (AP-1) transcription factors have been implicated in RA pathogenesis, the specific roles of individual AP-1 members in regulating synovial macrophages remain unclear. To address this, two public single-cell transcriptomic datasets were first analyzed to profile synovial macrophages, and then to identify AP-1 family members and associated pathways via differential expression and gene set enrichment analyses. JUND, FOSL2, and FOSB were found to be highly enriched in the RA synovium, and a distinct CXCL3⁺FOSL2⁺ macrophage subset was identified, characterized by pro-inflammatory, metabolic, and differentiatio

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12524658 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature