The Triglyceride Glucose-Conicity Index as a Novel Predictor for Stroke Risk: A Nationwide Prospective Cohort Study.

ABSTRACT: Background/Objectives: The triglyceride-glucose index (TyG) and conicity index (CI) are markers of insulin resistance and abdominal obesity, respectively. However, their joint impact on stroke remains unclear. This study aimed to assess the association between the novel composite TyG-conicity index (TyG-CI = TyG × CI) and stroke risk. Methods: This prospective cohort study enrolled 8011 participants aged 45 years or older with no history of stroke at baseline, from the China Health and Retirement Longitudinal Study. Cox proportional hazards regression models were used to estimate the impact of TyG-CI on the risk of incident stroke. Restricted cubic spline regressions were applied to estimate possible nonlinear associations. The predictive performance was evaluated using the a

SUBMITTER: Ye X 

PROVIDER: S-EPMC12524681 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature