Study of the Patterns of DNA Methylation in Human Cells Through the Prism of Intra-Strand DNA Symmetry.

ABSTRACT: Cellular organisms store heritable information in two forms, genetic and epigenetic, the latter being largely dependent on cytosine methylation (5mC). Chargaff's Second Parity Rule (CSPR) describes the nucleotide composition of cellular genomes in terms of intra-strand DNA symmetry. However, it remains unknown whether DNA methylation patterns display intra-strand DNA symmetry. Computational analysis was conducted of the DNA methylation patterns observed in human cell lines and in tissue samples from healthy donors. Analysis of 5mC marks in mutually reverse-complementary pairs of short oligomers, containing CpG dinucleotide in the middle, revealed deviations from CSPR and methylation asymmetry that can be observed for two non-overlapping mirror groups defined by CpG methylation values. Devi

SUBMITTER: Ramazanova Z 

PROVIDER: S-EPMC12524719 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature