Circulating MicroRNA Profiles in Pregnant South African Women with Different Types of Diabetes Mellitus.

ABSTRACT: Diabetes in pregnancy increases the risk of adverse perinatal outcomes for mother and child, with severity influenced by the type of diabetes and degree of hyperglycemia. This study aimed to identify circulating microRNAs (miRNAs) associated with different types of diabetes in pregnancy. Serum miRNAs were profiled in pregnant South African women with type 1 diabetes (T1DM), type 2 diabetes (T2DM), gestational diabetes (GDM), and normoglycemia using PCR arrays (n = 15). Differentially expressed miRNAs were validated in pregnant South African women (n = 167), and a separate cohort of Spanish pregnant women with T1DM and T2DM (n = 48). PCR arrays showed significant differential expression for miR-19b-3p (↓ 9.8-fold; p = 0.033) in GDM, miR-20a-5p (↓ 4.5-fold; p</

SUBMITTER: Masete M 

PROVIDER: S-EPMC12524793 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature