Metabolic and Endocrine Alterations in Underweight and Normal-Weight Women with Functional Hypothalamic Amenorrhea.

ABSTRACT: Background: Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation associated with hypoestrogenism. Weight loss, excessive exercise, stress and long-lasting hypoestrogenism lead to infertility and bone loss. FHA also leads to metabolic changes that increase cardiovascular risk in women who otherwise appear metabolically healthy. Methods: This was a case-control study assessing metabolic and endocrine alterations in patients with FHA, stratified by BMI into underweight (BMI < 18.5) and normal-weight (BMI 18.5-24.99) categories. Results: Women diagnosed with FHA had significantly higher levels of total (193 ± 41.96 vs. 181 ± 28.23 mg/dL; p = 0.037) and LDL cholesterol (67 ± 34.89 vs. 63 ± 24.78 mg/dL; p = 0.018) compared with healthy cont

SUBMITTER: Kowalczyk K 

PROVIDER: S-EPMC12524805 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature