Pharmacokinetic Alterations in Patients with Chronic Heart Failure: A Systematic Review.

ABSTRACT: (1) Chronic heart failure (CHF) is a typical component of the polymorbid profile of an elderly patient. The aim of this systematic review was to search for data from pharmacokinetic (PK) studies of any drugs in patients with CHF to systematize information on changes in PK parameters depending on the physicochemical properties (PCPs) of the drug and route of its administration. (2) A systematic review of PK studies in patients with CHF was performed using Elibrary.ru, United States National Library of Medicine (PubMed), China National Knowledge Infrastructure (CNKI), and Directory of Open Access Journals (DOAJ). The final number of included articles was 106. A descriptive and correlation analysis of PK data and PCPs of drugs included in the study was carried out. Inclusion criteria: PK stud

SUBMITTER: Butranova O 

PROVIDER: S-EPMC12524999 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature