Conserved function of a RasGEF-mediated pathway in the metabolic compensation of the circadian clock.

ABSTRACT: Metabolic compensation of the circadian clock ensures endogenous timing across a broad range of nutrient conditions, enabling organisms to adapt efficiently to recurrent environmental changes, even during nutrient scarcity. In this study, we have identified a novel clock-controlled gene, rasgef (Rat Sarcoma Guanine Nucleotide Exchange Factor), that plays a crucial role in modulating the circadian clock under starvation conditions in the circadian model organism Neurospora crassa. The gene product, RasGEF-a nucleotide exchange factor for the small G protein RAS2P (Rat Sarcoma 2 Protein)-displays glucose-dependent phosphorylation and localization. We show that deletion of rasgef hinders metabolic compensation of the circadian clock to glucose-depleted conditions and disrupts the rhythmic exp

SUBMITTER: Sarkany O 

PROVIDER: S-EPMC12525002 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature