Genomic Characterization of a Rare K30-ST198 Hypervirulent <i>Klebsiella pneumoniae</i> Clone with Distinctive Virulence Features.

ABSTRACT: Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a significant public health concern, yet rare sublineages remain poorly characterized. Here, we described a K30-ST198 hvKp sublineage identified in four isolates from two patients, including three sequential strains (K30B1, K30B2, K30B3) recovered over eight months from recurrent liver abscesses and one strain (K30-HUMV1) from a urinary tract infection. All isolates exhibited a yYpermucoviscous phenotype and resistance restricted to ampicillin and amoxicillin. Screening with the eazyplex hvKp assay detected ybt and rmpA in all strains, yielding a virulence score of 1. Biofilm production was strong in K30B1, K30B2, moderate in K30-HUMV1, but weak in K30B3. In the Galleria mellonella infection model, K30B1

SUBMITTER: Fernandez Vecilla D 

PROVIDER: S-EPMC12525063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature