Safety and Regenerative Properties of Immortalized Human Mesenchymal Stromal Cell Secretome.

ABSTRACT: The secretome of mesenchymal stromal cells (MSCs) can efficiently stimulate regeneration and therefore is a tempting remedy for "cell-free cellular therapy". However, the usage of primary MSC cultures as secretome producers for translation studies has obvious obstacles, including the rapid aging of MSC cultures, the need for a large number of verified donors, and donor-to-donor variability of secretome content. MSCs immortalization makes it possible to overcome those limitations and to obtain secretome-producing cultures with a prolonged lifetime. However, the efficacy and safety of such secretomes are critical issues that limit their usage as therapeutic agents. In this study, we tested in large detail how the immortalization of MSC cultures affects the content, biological activity and sa

SUBMITTER: Karagyaur M 

PROVIDER: S-EPMC12525087 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature