Intergenic Variants Upstream of GADD45b Affect Survival of <i>Micropterus salmoides</i> Following LMBV Exposure.

ABSTRACT: GADD45 (growth arrest and DNA damage inducible 45) is a crucial signaling regulator in cells and plays an important role in various biological processes, including cellular stress response, cell cycle control, DNA damage repair, apoptosis, and tumor suppression. Our previous studies identified GADD45b as a candidate gene associated with resistance to largemouth bass ranavirus (LMBV) infection in largemouth bass (Micropterus salmoides). In the present study, the upstream intergenic polymorphisms of GADD45b were investigated to explore their association with resistance/susceptibility to LMBV. We employed the kompetitive allele specific PCR (KASP) assay to genotype 118 resistant individuals and 122 susceptible individuals following LMBV infection. The results revealed that SNP38943374

SUBMITTER: Li P 

PROVIDER: S-EPMC12525184 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature