Pro-Inflammatory Cytokines as Early Predictors of Chronic Rheumatologic Disease Following Chikungunya Virus Infection.

ABSTRACT: Background/Objectives: Infection with the Chikungunya virus (CHIKV) results in acute febrile diseases with severe polyarthritis, which can be followed by chronic rheumatic disease and long-term disability. To evaluate cytokine profiles in acute and chronic CHIKV infection and examine the relationship with clinical outcomes, including persistent musculoskeletal symptoms. Methods: Literature search was carried out systematically using electronic databases (PubMed, Embase, Scopus, and Google Scholar). Studies that met eligibility criteria were observational or intervention cohorts that measured levels of cytokines/chemokines in laboratory-confirmed CHIKV patients in acute (<3 months) or chronic (>3 months) phases. Data was extracted on the study design, population, biomarkers, a

SUBMITTER: Conforti A 

PROVIDER: S-EPMC12525192 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature