Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD), the most prevalent form of dementia, poses a critical global health challenge as its incidence rises with aging populations. Despite extensive research into its genetic and molecular underpinnings, effective therapeutic strategies remain limited. Growing evidence suggests that physical exercise may offer neuroprotective benefits, potentially mitigating AD progression through multifactorial mechanisms. This review synthesizes current findings on the interplay between aerobic exercise and AD pathophysiology, with a focus on amyloid-β (Aβ) metabolism, gene expression, and neuroinflammation. We explore how exercise influences Aβ clearance, modulates amyloid precursor protein (APP) processing, and impacts the activity of key enzymes such as secretases and neprilysin. F

SUBMITTER: Astorino MF 

PROVIDER: S-EPMC12525307 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature