Antibacterial Activity of Bis(4-aminopyridinium) Compounds for Their Potential Use as Disinfectants.

ABSTRACT: The following study presents the initial evaluation (solubility, thermal stability, antibacterial activity, and cytotoxicity) of a series of previously described organic salts, derived from the bis(4-aminopyridinium) cation with different chain lengths, for their potential use as hospital disinfectants. Of the salts studied, those with chain lengths between 2 and 10 carbon atoms (C₂-C₁₀) showed high solubility in water, methanol, and DMSO. All salts exhibited high thermal stability, showing a thermal decomposition temperature (T_5%) above 330 °C. Antibiotic susceptibility testing of the studied E. coli, S. aureus, and S. typhimurium strains confirmed their resistance to different classes of commonly used clinical antibiotics, validating

SUBMITTER: Arriaza-Echanes C 

PROVIDER: S-EPMC12525534 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature