The Regulation of the Albomycin and Desferrioxamine E Biosynthesis in <i>Streptomyces globisporus</i> bja209.

ABSTRACT: We identified Streptomyces globisporus bja209 through a targeted screen of actinomycetes from natural habitats using an E. coli JW5503 ΔtolC DualRep2(c) reporter strain. This strain produced antibacterial compounds whose action depended on the growth medium. HPLC-MS and genomic analysis revealed two metabolites: albomycin δ2 (a translation inhibitor) and desferrioxamine E. The latter induced the SOS response. Desferrioxamine E exhibited a narrow spectrum of antagonistic activity against carbapenem-resistant A. baumannii and C. michiganensis, and its production was critically regulated by iron concentration. Notably, the structurally similar desferrioxamine B was inactive. Contrary to previous reports, pangenome analysis of published GenBank genomes revealed that

SUBMITTER: Buyuklyan JA 

PROVIDER: S-EPMC12525621 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature