Chitosan-<i>graft</i>-poly(<i>N</i>-vinylcaprolactam) Nanoparticles Containing <i>Crotalus atrox</i> Snake Venom: Biological and Physicochemical Characterization.

ABSTRACT: The development of snake venom-loaded nanobiosystems based on smart biopolymers represents a promising therapeutic approach in several biomedical research fields. Specifically, the western diamondback rattlesnake (Crotalus atrox) contains various bioactive peptides and proteins with reported antitumor activity. This research aimed to establish a simplistic, facile and straightforward protocol for preparing chitosan-g-poly(N-vinylcaprolactam) nanoparticles containing C. atrox venom for potential use as a therapeutic nanocarrier against breast carcinoma cell lines. Herein, the physicochemical properties of venom-loaded nanoparticles were evaluated by FTIR, DLS, and SDS-PAGE. Also, the biological properties of both C. atrox venom and Cs-Venom NPs such as hem

SUBMITTER: Rudy SS 

PROVIDER: S-EPMC12525661 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature