Total Cholesterol and Mortality in Older Adults: A Sex-Stratified Cohort Study.

ABSTRACT: Background: The relationship between total cholesterol (TC) levels and mortality in older adults is complex and may differ from younger populations. While hypercholesterolemia is a known midlife risk factor, this association may weaken or reverse with age. Biological differences in cholesterol metabolism-particularly hormonal changes-may contribute to sex-specific mortality risks, but this remains underexplored. We examined the association between TC and all-cause mortality in older adults, assessing sex-specific differences. Methods: We used data from the InCHIANTI study, a longitudinal, population-based study conducted in Tuscany, Italy. From the original cohort (N = 1453), 999 participants ≥ 65 years with baseline TC and mortality data were included. TC levels were categor

SUBMITTER: Iuorio MS 

PROVIDER: S-EPMC12525712 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature