Diastereoselective Reformatsky Reaction Mediated by Dichlorocyclopentadienyltitanium(III).

ABSTRACT: The Reformatsky reaction, first reported in 1887, has long been recognized as a fundamental method for carbon-carbon bond construction due to its mild conditions and functional group tolerance. Over the past few decades, this transformation has undergone a notable revival, with modern catalytic variants addressing limitations of stoichiometric protocols and expanding its role in complex molecule synthesis. Yet, despite its versatility, achieving stereoselective control remains a longstanding challenge. Herein we report the use of dichlorocyclopentadienyltitanium(III) (CpTiCl₂), generated in situ from CpTiCl₃ and manganese, as an efficient catalyst for Reformatsky-type couplings of aldehydes with α-haloesters and α-iodonitriles. Under mild conditions, CpTiCl₂

SUBMITTER: Lopez-Martinez JL 

PROVIDER: S-EPMC12525768 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature