Performance Characteristics for Physiological Measures of Progressive Pulmonary Fibrosis.

ABSTRACT: Rationale: Clinical measures of progressive pulmonary fibrosis (PPF) have been proposed, but their clinical utility remains unclear. Objectives: To determine performance characteristics of lung function-based PPF measures, including new guideline criteria for discriminating clinically relevant outcomes. Methods: A multicenter retrospective cohort analysis was performed to assess the performance characteristics of eight categorical measures of FVC and Dl_CO decline, together with PPF guideline criteria (requiring two of the following: worsening respiratory symptoms, absolute decline in FVC ⩾5% or Dl_CO ⩾15%, or radiological progression) for discriminating 2-year death or lung transplant among patients fibrotic interstitial lung disease from the Unite

SUBMITTER: Newton CA 

PROVIDER: S-EPMC12525792 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature