Metal Transporter Gene <i>SLC39A8</i> Polymorphism rs13107325 and Dietary Manganese Intake Are Associated with Measures of Cardiovascular Disease Risk in a UK Biobank Population Cohort.

ABSTRACT: Background/Objectives: Metal transporter gene SLC39A8 and single nucleotide polymorphism (SNP) rs13107325 are associated with risk factors for atherosclerosis and cardiovascular disease (CVD). However, it is unclear how dietary manganese intake impacts CVD risk factors. The aim of this study was to use the UK Biobank population cohort (276,436 participants, Caucasian genetic ancestry, no genetic kinship) to investigate whether rs13107325 and dietary manganese are associated with CVD risk. Methods: A cross-sectional design and quantile (median) regression was used to determine associations of rs13107325 and dietary manganese intake with indicators of CVD risk. Results: SNP rs13107325 was associated with CVD risk factors, including greater body mass index (BMI) (b

SUBMITTER: Sigdel R 

PROVIDER: S-EPMC12525855 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature